Analytical Data
-
基因名
GJA4
- Application
-
别名
GJA4; Gap junction alpha-4 protein; Connexin-37; Cx37
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P35212
-
表达区间
1-333aa
-
氨基酸序列
MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCLSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWANLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV
-
分子量
63.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GJA4, also known as Connexin 37, is a member of the connexin family of proteins that form gap junctions, facilitating intercellular communication in various tissues. Research into GJA4 has gained significant attention due to its crucial role in cardiovascular health, particularly in endothelial function and vascular homeostasis. Mutations or dysregulation of GJA4 have been implicated in various cardiovascular diseases, including hypertension and atherosclerosis. Moreover, studies have suggested that GJA4 may influence cellular responses to stress and injury, further highlighting its importance in maintaining cellular integrity. Understanding the structure-function relationship of GJA4 is essential for deciphering its specific roles in different tissues and disease processes. Recent advances in recombinant protein technology have paved the way for the production of GJA4 in a controlled environment, allowing researchers to study its properties in detail. This has led to significant insights into its oligomerization, channel-forming abilities, and interaction with other proteins, supporting the notion that GJA4 is integral to vascular biology. Overall, the exploration of GJA4 and its recombinant forms holds promise for therapeutic interventions aimed at mitigating cardiovascular diseases and enhancing vascular health.
