Analytical Data
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Gene name
FTSJ1
- Application
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Alternative Names
2'-O-ribose RNA methyltransferase TRM7 homolog
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UET6
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Expression Region
1-329aa
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Molecular Weight
40.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FTSJ1, a member of the methyltransferase family, plays a crucial role in RNA modification, specifically in the methylation of 2'-O-ribose of ribosomal RNA. This modification is essential for the proper biogenesis and function of ribosomes, which are vital for protein synthesis in all living cells. Dysregulation of FTSJ1 has been linked to various diseases, including certain types of cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Researchers have increasingly focused on the recombinant production of FTSJ1 to study its enzymatic activity, understand its structural dynamics, and explore its interaction with RNA substrates. The recombinant FTSJ1 protein allows for the detailed investigation of its methyltransferase activity under controlled conditions, paving the way for high-throughput screenings of small molecules that could modulate its function. Furthermore, structural studies on the recombinant protein provide insights into its mechanistic pathways and offer clues for developing inhibitors or activators with potential clinical applications. As such, the study of FTSJ1 recombinant protein not only enhances our understanding of fundamental biological processes but also opens avenues for novel therapeutic strategies targeting RNA modifications in disease contexts.
