Analytical Data
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基因名
Cyp3a11
- Application
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别名
(CYPIIIA11)(Cytochrome P-450IIIAM1)(Cytochrome P-450UT)
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种属
Mouse
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q64459
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表达区间
1-504aa
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分子量
65.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP3A11 is a member of the cytochrome P450 superfamily of enzymes, primarily involved in the metabolism of various endogenous and exogenous compounds, including drugs and steroids. Its role in pharmacokinetics and toxicology has garnered significant attention, particularly due to its potential impact on drug efficacy and safety. Variations in CYP3A11 expression and activity can lead to interindividual differences in drug metabolism, making it a critical target for personalized medicine approaches. Understanding the functional characteristics of CYP3A11 requires the production of recombinant protein, allowing researchers to study its enzymatic activity in vitro. Additionally, the recombinant CYP3A11 protein serves as a valuable tool for exploring drug-drug interactions, as well as for screening potential drug candidates. With the increasing focus on precision pharmacotherapy, characterizing the biochemical properties and mechanisms of CYP3A11 will pave the way for optimizing therapeutic strategies and minimizing adverse drug reactions in diverse patient populations. As such, research into the recombinant expression and functional analysis of CYP3A11 is crucial for advancing our knowledge of metabolic pathways and enhancing the safety and effectiveness of pharmacological treatments.
