Analytical Data
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基因名
MERTK
- Application
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别名
MERTK；MER；Tyrosine-Protein kinase Mer
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12866
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表达区间
578-872aa
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氨基酸序列
EDV VIDRNLLILG KILGEGEFGS VMEGNLKQED GTSLKVAVKT MKLDNSSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS SQGIPKPMVI LPFMKYGDLH TYLLYSRLET GPKHIPLQTL LKFMVDISLG MEYLSNRNFL HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK SDVWAFGVTM WEIATRGMTP YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMYSCWRTD PLDRPTFSVL RLQLEKLLES LPDVRNQADV IY
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分子量
58 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MERTK (Mer Tyrosine Kinase) is a receptor tyrosine kinase that plays a crucial role in various biological processes, including cell differentiation, immune response, and the clearance of apoptotic cells. Dysregulation of MERTK signaling has been implicated in several diseases, particularly in cancer and autoimmune disorders. The interest in MERTK as a therapeutic target has grown due to its involvement in tumor progression and immune evasion, making it a potential candidate for cancer immunotherapy. Research has shown that MERTK can modulate the immune response by facilitating the uptake of apoptotic cells, thereby promoting an anti-inflammatory environment. Recombinant MERTK proteins have been developed to study its structure, function, and interaction with other molecules. These proteins serve as valuable tools for understanding the mechanisms underlying MERTK signaling and its role in disease. Additionally, the development of MERTK-targeted therapies, including monoclonal antibodies and small molecule inhibitors, is being explored in preclinical and clinical settings. As such, the study of recombinant MERTK proteins is essential for elucidating the pathways involved in its signaling and for advancing potential therapeutic strategies aimed at modulating MERTK activity in various pathological conditions.
