Analytical Data
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基因名
GCNT3
- Application
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别名
GCNT3; Beta-1.3-galactosyl-O-glycosyl-glycoprotein beta-1.6-N-acetylglucosaminyltransferase 3; C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1.6-N-acetylglucosaminyltransferase; C2/4GnT
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95395
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表达区间
28-126aa
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氨基酸序列
KLSFRLKCDSDHLGLESRESQSQYCRNILYNFLKLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFIQFPLSK
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GCNT3 (Group 3 Glycosyltransferase 6) is a member of the glycosyltransferase family that plays a critical role in the biosynthesis of glycoproteins and glycolipids, influencing various biological processes such as cell adhesion, signaling, and immune response. The enzyme specifically catalyzes the addition of glycan structures to the antigen Kamino to form the Lewis X structure, which is vital for cell-cell interactions and recognition in physiological and pathological contexts. Aberrant expression of GCNT3 has been associated with several diseases, including cancer, where altered glycosylation patterns can contribute to tumor progression and metastasis. Understanding the biochemical properties and functional implications of GCNT3 is crucial for revealing its potential as a biomarker or therapeutic target. Recombinant GCNT3 protein can be produced to facilitate detailed studies of its enzymatic activity, substrate specificity, and interaction with other cellular components. This research aims to elucidate the molecular mechanisms underlying its role in glycosylation pathways and their impact on cellular behavior, thus contributing to the broader field of glycobiology and its application in disease diagnosis and treatment strategies.
